Effect of arginine on cyclosporine-induced systemic hypertension after cardiac transplantation in the young

被引：2

作者：

Gomez, CA

Crowley, DC

D'Alecy, L

Goldberg, CS

Charpie, JR

机构：

[1] Univ Michigan, Med Ctr, Dept Pediat, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Med Ctr, Dept Communicable Dis, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Med Ctr, Dept Physiol, Ann Arbor, MI 48109 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 87卷 / 07期

关键词：

D O I：

10.1016/S0002-9149(00)01544-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To test the hypothesis that cyclosporine-induced hypertension is associated with an altered L-arginine/nitric oxide pathway, we studied the acute effects of intravenous L-arginine infusion on blood pressure, heart rate, left ventricular function, and nitric oxide production in young heart transplant patients receiving cyclosporine. Results demonstrate that L-arginine can significantly reduce blood pressure in heart transplant patients, with a concomitant increase in nitric oxide production.

引用

收藏

页码：927 / +

页数：5

相关论文

共 11 条

[1] SUPPRESSION OF NITRIC-OXIDE PRODUCTION BY CYCLOSPORINE-A AND FK506A IN RAT VASCULAR SMOOTH-MUSCLE CELLS [J].

AKITA, K ;

DUSTING, GJ ;

HICKEY, H .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1994, 21 (03) :231-233

[2] Modulation of nitric oxide improves cyclosporin A-induced hypertension in rats and primates [J].

Bartholomeusz, B ;

Hardy, KJ ;

Nelson, AS ;

Phillips, PA .

JOURNAL OF HUMAN HYPERTENSION, 1998, 12 (12) :839-844

[3] MECHANISMS OF THE ENDOTHELIAL TOXICITY OF CYCLOSPORINE-A ROLE OF NITRIC-OXIDE, CGMP, AND CA2+ [J].

GALLEGO, MJ ;

VILLALON, ALG ;

FARRE, AJL ;

GARCIA, JL ;

GARRON, MP ;

CASADO, S ;

HERNANDO, L ;

CARAMELO, CA .

CIRCULATION RESEARCH, 1994, 74 (03) :477-484

[4] SHORT-TERM PULMONARY VASODILATION WITH L-ARGININE IN PULMONARY-HYPERTENSION [J].

MEHTA, S ;

STEWART, DJ ;

LANGLEBEN, D ;

LEVY, RD .

CIRCULATION, 1995, 92 (06) :1539-1545

[5] Role of nitric oxide in cyclosporine A-induced hypertension [J].

Oriji, GK ;

Keiser, HR .

HYPERTENSION, 1998, 32 (05) :849-855

[6] Nitric oxide in cyclosporine A-induced hypertension: endothelin receptors gene expression [J].

Oriji, GK .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1999, 61 (01) :41-44

[7] Oral arginine restores endothelium-dependent vasodilation in cyclosporine treated rats [J].

Prieto, M ;

Escallada, R ;

Cobo, M ;

Cotorruelo, JG ;

Morales, P ;

deFrancisco, ALM ;

Rodrigo, E ;

Sanz, S ;

Arias, M .

TRANSPLANTATION PROCEEDINGS, 1997, 29 (1-2) :1244-1245

[8] CYCLOSPORINE-A INHIBITS RELAXATION BUT DOES NOT INDUCE VASOCONSTRICTION IN HUMAN SUBCUTANEOUS RESISTANCE VESSELS [J].

RICHARDS, NT ;

POSTON, L ;

HILTON, PJ .

JOURNAL OF HYPERTENSION, 1989, 7 (01) :1-3

[9] Pharmacokinetics of intravenous and oral L-arginine in normal volunteers [J].

Tangphao, O ;

Grossmann, M ;

Chalon, S ;

Hoffman, BB ;

Blaschke, TF .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1999, 47 (03) :261-266

[10]

VANHAEFTEN TW, 1989, CLIN CHEM, V35, P1024