Synthesis of Monofluoroalkenes via the Activation of Allylic C-F Bonds: A Novel Route to β-Aminofluoroalkenes Using Pd-Catalyzed Allylic Amination Reactions of 3,3-Difluoropropenes

被引：54

作者：

Paquin, Jean-Francois ^{[1
]}

机构：

[1] Univ Laval, Canada Res Chair Organ & Med Chem, Dept Chim, Quebec City, PQ G1V 0A6, Canada

来源：

SYNLETT | 2011年 / 03期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

C-F activation; organofluorine chemistry; fluoroalkenes; palladium; homogeneous catalysis; CARBON-FLUORINE BONDS; ASYMMETRIC FLUORINATION; CHLORIDE-IONS; SUBSTITUTION; TRIFLUOROMETHYLATION; PHARMACEUTICALS; HYDROGENOLYSIS; FLUOROOLEFINS; NUCLEOPHILES; MECHANISM;

D O I：

10.1055/s-0030-1259333

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This article portrays the development of a novel and efficient synthetic route to beta-aminofluoroalkenes, from readily available 3,3-difluoropropenes and amines, that proceeds via the activation of an allylic C-F bond.

引用

页码：289 / 293

页数：5

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