Virus variation, escape from cytotoxic T lymphocytes and human retroviral persistence

被引：7

作者：

Gould, KG ^{[1
]}

Bangham, CRM ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1998年 / 9卷 / 03期

基金：

英国惠康基金;

关键词：

virus; sequence variation; mutation selection; immune escape;

D O I：

10.1006/scdb.1998.0241

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Viruses use a variety of mechanisms to escape recognition by cytotoxic T lymphocytes (CTL). The available evidence suggests that the main mechanisms of CTL escape caused by viral sequence variation are loss of epitope binding to MHC molecules or altered recognition by T cell receptors. These types of mutations occur in both human immunodeficiency virus type 1 (HIV-1) and human T cell leukaemia virus type 1 (HTLV-1) infections. In HIV-1, CTL escape is one factor that may cause progression of disease. In HTLV-I, however, CTL escape mutants never predominate in the viral population.

引用

页码：321 / 328

页数：8

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