Regulation of inflammation-related genes in human adipose tissue

被引:76
作者
Clement, K. [1 ]
Langin, D.
机构
[1] INSERM, U755 Nutriom, F-75004 Paris, France
[2] Univ Paris 06, Fac Med Cordeliers, F-75252 Paris 05, France
[3] Hop Hotel Dieu, APHP, Dept Nutr, F-75181 Paris, France
[4] Fac Med Toulouse, INSERM, U858, Unite Rech Obes, F-31073 Toulouse, France
[5] Univ Toulouse 3, Inst Louis Bugnard, IFR31, F-31062 Toulouse, France
[6] CHU Toulouse, Inst Federat Biol Purpan, Biochim Lab, Toulouse, France
[7] INSERM, Franco Czech Lab Clin Res Obes, Prague, Czech Republic
关键词
adipose tissue; gene expression; inflammation; macrophages; obesity;
D O I
10.1111/j.1365-2796.2007.01851.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The identification of a moderate increase in circulating inflammatory factors in obese subjects, the description of changes in inflammatory gene expression in adipose tissue (AT) and the discovery that macrophage cells infiltrate AT are observations contributing to the concept that human obesity is a chronic inflammatory illness. This concept has led to some revision of the physiopathology of obesity and of its related metabolic and cardiovascular co-morbidities. Low-grade inflammation in the AT and the subsequent production of specific biomarkers could actually link expanded fat mass to obesity complications. This review aims at providing an overview of the current knowledge brought up by human gene expression studies, notably those performed on a large scale in AT depots. The regulation of specific biomarkers related to inflammation and putative new candidates (i.e. cathepsins and serum amyloid A) is discussed in the context of weight loss programmes based on calorie restriction and physical exercise. The foreseen clinical and technological challenges are also summarized.
引用
收藏
页码:422 / 430
页数:9
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