Catalytic hydrogenation of ethyl 2-amino-2-difluoromethyl-4-cyanobutanoate and its Schiff base reaction modes

被引：10

作者：

Zhu, JY ^{[1
]}

Price, BA ^{[1
]}

Walker, J ^{[1
]}

Zhao, SX ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Proc Res & Dev, New Brunswick, NJ 08903 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 16期

关键词：

eflornithin; catalytical hydrogenation; catalyst; nitrile reduction;

D O I：

10.1016/j.tetlet.2005.02.146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under heterogeneous catalysis, ethyl 2-amino-2-difluoromethyl-4-cyanobutanoate or its Schiff base could be selectively reduced in good yield by hydrogenation to give a diamine, or to form a five-membered ring or a six-membered ring heterocycles. This selectivity is highly dependent on the type of catalysts used. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2795 / 2797

页数：3

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