Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain

被引：41

作者：

Gonzalez-Fernandez, Maria C. ^{[1
,2
]}

Lezcano, Elena ^{[3
]}

Ross, Owen A. ^{[2
]}

Gomez-Esteban, Juan C. ^{[3
]}

Gomez-Busto, Fernando ^{[4
]}

Velasco, Fernando ^{[3
]}

Alvarez-Alvarez, Maite ^{[1
]}

Rodriguez-Martinez, Maria B. ^{[1
]}

Ciordia, Roberto ^{[3
]}

Zarranz, Juan J.

Farrer, Matthew J. ^{[2
]}

Mata, Ignacio F. ^{[2
,5
]}

de Pancorbo, Marian M. ^{[1
]}

机构：

[1] Univ Basque Country, Dept Biol Celular, Banco de ADN, Serv Gen Invest Genom, Vitoria, Spain

[2] Mayo Clin, Dept Neurosci, Jacksonville, FL USA

[3] Hosp Cruces, Serv Neurol, Baracaldo, Spain

[4] Residencia Tercera Edad San Prudencio Ayuntamient, Serv Geriatr, Vitoria, Spain

[5] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

来源：

PARKINSONISM & RELATED DISORDERS | 2007年 / 13卷 / 08期

关键词：

Parkinson's disease; LRRK2; dardarina; Spain; mutation;

D O I：

10.1016/j.parkreldis.2007.04.003

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Herein we describe a comparative clinical and genetic study of Lrrk2-associated parkinsonism in Northern Spain. In our sample from the Basque region, Lrrk2 R1441G and G2019S account for 15 out of 50 kindreds (30%) with familial Parkinson's disease. We observe common founder haplotypes for both R 1441 G and G2019S carriers. Our findings highlight the importance of Lrrk2 parkinsonism in this population and may have important consequences for its extended Diaspora in North, Central and South Americas. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：509 / 515

页数：7

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