QT prolongation and Torsades de Pointes in patients infected with human immunodeficiency virus and treated with methadone

被引：83

作者：

Gil, M

Sala, M

Anguera, I

Chapinal, O

Cervantes, M

Guma, JR

Segura, F

机构：

[1] Corporacio Sanitaria Parc Tauli, Hosp Sabadell, Infect Dis Unit, Dept Internal Med, Sabadell, Barcelona, Spain

[2] Corporacio Sanitaria Parc Tauli, Hosp Sabadell, Dept Cardiol, Dept Internal Med, Sabadell, Barcelona, Spain

[3] CAS Drogodependencies Sabadell, Barcelona, Spain

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(03)00906-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Four patients infected with human immunodeficiency virus receiving antiretroviral treatment and high doses of methadone (>200 mg/day) presented with several syncopal episodes. A significant prolongation of the QTc interval was detected in all of them, and in 3 patients, greater than or equal to1 episode of Torsades de Pointes was recorded. The sequence of events in these cases suggests that high doses of methadone caused QT prolongation and provided the substrate for syncope and Torsades de Pointes. (C) 2003 by Excerpta Medica, Inc.

引用

页码：995 / 997

页数：3

共 8 条

[1]

Beauverie P, 1998, AIDS, V12, P2510

[2] Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs:: A call for consensus [J].