The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic Neisseria and Haemophilus

被引:61
作者
Harvey, HA [1 ]
Swords, WE [1 ]
Apicella, RA [1 ]
机构
[1] Univ Iowa, Coll Med, Dept Microbiol, Iowa City, IA 52242 USA
关键词
mucosal pathogens; human asialoglycoprotein receptor; platelet-activating factor receptor pK antigen; i antigen; paragloboside;
D O I
10.1006/jaut.2000.0477
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cells. These structures are important in the pathogenesis of Neisseria and Haemophilus species for both immune evasion and in the adherence and invasion of human cells. There is no evidence that colonization or infections by these bacterial species is associated with autoimmune disease. (C) 2001 Academic Press.
引用
收藏
页码:257 / 262
页数:6
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