Twenty-Five Years of Translational Medicine in Antiretroviral Therapy: Promises to Keep

被引：17

作者：

Broder, Samuel ^{[1
]}

机构：

[1] Celera Corp, Rockville, MD 20850 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2010年 / 2卷 / 39期

关键词：

PLACEBO-CONTROLLED TRIAL; HIV PROTEASE INHIBITORS; AIDS-RELATED COMPLEX; 3'-AZIDO-2'; 3'-DIDEOXYTHYMIDINE AZT; REVERSE-TRANSCRIPTASE; KAPOSIS-SARCOMA; HTLV-III/LAV; T-CELLS; REPLICATION; 3'-AZIDO-3'-DEOXYTHYMIDINE;

D O I：

10.1126/scitranslmed.3000749

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The year 2010 marks the 25th anniversary of modern antiretroviral drug discovery and development. In the early 1980s, AIDS was almost always a lethal disease with an appalling clinical course characterized by severe opportunistic infections and unusual forms of cancer. Since that time, starting with zidovudine (AZT) and related 2',3'-dideoxynucleosides, the causative retrovirus, now called HIV-1, went from being an untreatable infectious agent to being the target of highly active antiretroviral therapy (HAART). This degree of progress refuted early prophesies of therapeutic futility and represents a striking example of translational medicine. Here I review foundational discoveries and events in HIV-1/AIDS research and explore lessons for future translational medicine efforts.

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页数：6

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