Innate and adaptive functions of the CD1 pathway of antigen presentation

被引：18

作者：

Park, SH ^{[1
]}

Chiu, YH ^{[1
]}

Jayawardena, J ^{[1
]}

Roark, J ^{[1
]}

Kavita, U ^{[1
]}

Bendelac, A ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

SEMINARS IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

CD1; T cells; innate immunity; interleukin-4; glycolipids;

D O I：

10.1006/smim.1998.0139

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past few years, several studies have unravelled a novel pathway of antigen presentation to T cells of the mammalian immune system. The antigens are presented by CD1, which appears to have evolved to present glycolipid antigens to alpha beta T cells. CD1-restricted T cells are frequently autoreactive, and can promptly release key regulatory cytokines such as IL-4 and IFN-gamma. They have been implicated in a variety of autoimmune diseases including type I diabetes and lupus, in intracellular bacterial infections, and in tumor rejection. They are likely to be involved at the early, innate phase of these immune responses, providing a unique model to study the interface between the innate and adaptive immune systems.

引用

页码：391 / 398

页数：8

共 57 条

[1] Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].