Tumor microenvironment and hemorheological abnormalities

被引：16

作者：

Baronzio, G

Freitas, I

Kwaan, HC

机构：

[1] Univ Pavia, Dipartimento Biol Anim, I-27100 Pavia, Italy

[2] ASL 1 Legnano, Family Med Area, Milan, Italy

[3] Univ Pavia, CNR, Inst Genet Mol, I-27100 Pavia, Italy

[4] Northwestern Univ, Feinberg Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA

来源：

SEMINARS IN THROMBOSIS AND HEMOSTASIS | 2003年 / 29卷 / 05期

关键词：

hypoxia; tumor interstitial fluid; VEGF; thrombosis; hemorheology;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

引用

页码：489 / 497

页数：9

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