Total synthesis of TMC-95A

被引：69

作者：

Inoue, M ^{[1
]}

Sakazaki, H ^{[1
]}

Furuyama, H ^{[1
]}

Hirama, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Sci, Sendai, Miyagi 9808578, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 23期

关键词：

biaryls; macrocycles; natural products; olefination; total synthesis;

D O I：

10.1002/anie.200351130

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Suzuki-Miyaura coupling reaction to form C1-C20, macrolactamization at N9-C10, and a mild decarboxylative anti elimination to selectively introduce the (Z)-1-propenylamide are key steps in a highly convergent and completely stereo-selective synthesis of the potent proteasome inhibitor TMC-95A (see structure).

引用

页码：2654 / 2657

页数：4

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