DNA dynamics in a microchannel

被引：173

作者：

Jendrejack, RM ^{[1
]}

Dimalanta, ET

Schwartz, DC

Graham, MD

de Pablo, JJ

机构：

[1] Univ Wisconsin, Dept Biol & Chem Engn, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[3] Univ Wisconsin, Genet Lab, Madison, WI 53706 USA

[4] 3M Co, St Paul, MN 55144 USA

来源：

PHYSICAL REVIEW LETTERS | 2003年 / 91卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevLett.91.038102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

An extended Brownian dynamics simulation method is used to characterize the dynamics of long DNA molecules flowing in microchannels. The relaxation time increases due to confinement in agreement with scaling predictions. During flow the molecules migrate toward the channel center line, and thereby segregate according to molecular weight. Capturing these effects requires the detailed incorporation of solvent flow in the simulation method, demonstrating the importance of hydrodynamic effects in the dynamics of confined macromolecules.

引用

页数：4

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