Convergent diversity-oriented synthesis of small-molecule hybrids

被引:77
作者
Chen, C
Li, XD
Neumann, CS
Lo, MMC
Schreiber, SL
机构
[1] Harvard Univ, Howard Hughes Med Inst, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
[2] Broad Inst Harvard, Cambridge, MA 02138 USA
[3] MIT, Cambridge, MA 02138 USA
关键词
convergent synthesis; diversity-oriented synthesis; polycycles; small-molecule hybrids; solid-phase synthesis;
D O I
10.1002/ANIE.200462798
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:2249 / 2252
页数:4
相关论文
共 22 条
[1]  
Baldino CM, 1997, SYNLETT, P488
[2]   A one-bead, one-stock solution approach to chemical genetics:: part 1 [J].
Blackwell, HE ;
Pérez, L ;
Stavenger, RA ;
Tallarico, JA ;
Eatough, EC ;
Foley, MA ;
Schreiber, SL .
CHEMISTRY & BIOLOGY, 2001, 8 (12) :1167-1182
[3]  
Boger D. L., 2003, ANGEW CHEM, V115, P4270
[4]   Solution-phase combinatorial libraries: Modulating cellular signaling by targeting protein-protein or protein-DNA interactions [J].
Boger, DL ;
Desharnais, J ;
Capps, K .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (35) :4138-4176
[5]  
Breinbauer R, 2002, ANGEW CHEM INT EDIT, V41, P2879
[6]  
BREINBAUER R, 2002, ANGEW CHEM, V114, P3002
[7]  
Burke M. D., 2004, ANGEW CHEM, V116, P48
[8]   A planning strategy for diversity-oriented synthesis [J].
Burke, MD ;
Schreiber, SL .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (01) :46-58
[9]   Catalytic asymmetric [3+2] cycloaddition of azomethine ylides. Development of a versatile stepwise, three-component reaction for diversity-oriented synthesis [J].
Chen, C ;
Li, XD ;
Schreiber, SL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (34) :10174-10175
[10]   Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: A general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides [J].
Chen, Y ;
Bilban, M ;
Foster, CA ;
Boger, DL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (19) :5431-5440