Novel route to the synthesis of hydroxylated piperidine and pyrrolidine derivatives via the intramolecular reaction of gamma-aminoallylstannane with aldehyde

被引：15

作者：

Kadota, I ^{[1
]}

Kawada, M ^{[1
]}

Saya, S ^{[1
]}

Yamamoto, Y ^{[1
]}

机构：

[1] TOHOKU UNIV,DEPT CHEM,GRAD SCH SCI,SENDAI,MIYAGI 98077,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 12期

关键词：

D O I：

10.1016/0040-4039(96)00205-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Lewis acid mediated intramolecular reaction of gamma-aminoallylstannane 6 gave trans-beta-hydroxypiperidine derivative 7a as a major product. On the other hand, the thermal cyclization of 6 and 8 afforded cis-beta hydroxypiperidine 7b and pyrrolidine derivative 9b, respectively, with very high stereoselectivity.

引用

页码：2109 / 2112

页数：4

共 12 条

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