Bone formation on carbon nanotube composite

被引：49

作者：

Bhattacharya, Mrinal ^{[2
]}

Wutticharoenmongkol-Thitiwongsawet, Patcharaporn ^{[3
]}

Hamamoto, Darryl T. ^{[1
]}

Lee, Dongjin ^{[4
]}

Cui, Tianhong ^{[4
]}

Prasad, Hari S. ^{[1
]}

Ahmad, Mansur ^{[1
]}

机构：

[1] Univ Minnesota, Sch Dent, Dept Diagnost & Biol Sci, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Bioprod & Biosyst Engn, St Paul, MN 55108 USA

[3] Prince Songkla Univ, Polymer Sci Program, Fac Sci, Hat Yai, Thailand

[4] Univ Minnesota, Dept Mech Engn, Minneapolis, MN 55455 USA

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2011年 / 96A卷 / 01期

关键词：

carbon nanotube; osteoblast; titanium; critical sized defect; mineralization; MECHANICAL-PROPERTIES; IN-VITRO; SURFACE-ROUGHNESS; OXIDATIVE STRESS; CELL-CULTURE; BIOCOMPATIBILITY; OSTEOBLASTS; NANOINDENTATION; KERATINOCYTES; MICROSCOPY;

D O I：

10.1002/jbm.a.32958

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

The effects of a layer-by-layer assembled carbon nanotube composite (CNT-comp) on osteoblasts in vitro and bone tissue in vivo in rats were studied. The effects of CNT-comp on osteoblasts were compared against the effects by commercially pure titanium (cpTi) and tissue culture dishes. Cell proliferation on the CNT-comp and cpTi were similar. However, cell differentiation, measured by alkaline phosphatase activity and matrix mineralization, was better on the CNT-comp. When implanted in critical-sized rat calvarial defect, the CNT-comp permitted bone formation and bone repair without signs of rejection or inflammation. These data indicate that CNT-comp may be a promising substrate for use as a bone implant or as a scaffold for tissue engineering. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 96A: 75-82, 2011.

引用

页码：75 / 82

页数：8

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