Down syndrome and mouse models

被引：49

作者：

Kola, I ^{[1
]}

Hertzog, PJ ^{[1
]}

机构：

[1] Monash Univ, Inst Reprod & Dev, Mol Genet & Dev Grp, Clayton, Vic 3168, Australia

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(98)80088-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The past year has seen major advancements in the characterisation of the Ts65Dn mouse model (which is now known to display many features of Down syndrome). A newer model that is trisomic for the region 21q22.2 - previously called 'Down syndrome' region - has been generated and these mice display behavioural and learning defects. Mutations in the genes Minibrain and SOD1 have been implicated in the development of learning defects in Down syndrome and many new genes from human chromosome 21 are being cloned, which should result in the genesis of other models that phenocopy one or more pathologies of the syndrome.

引用

页码：316 / 321

页数：6

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