Evidence for and against regional differences in neural stem and progenitor cells of the CNS

被引：10

作者：

Becher, Oren J. ^{[4
,5
]}

Holland, Eric C. ^{[1
,2
,3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Neurosurg, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Canc Biol & Genet, New York, NY 10021 USA

[3] Mem Sloan Kettering Canc Ctr, Brain Tumor Ctr, New York, NY 10021 USA

[4] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Preston Robert Tisch Brain Tumor Ctr, Durham, NC 27710 USA

来源：

GENES & DEVELOPMENT | 2010年 / 24卷 / 20期

关键词：

Neurofibromin; neural stem cell; regional heterogeneity; gliogenesis; Akt; mTOR; CENTRAL-NERVOUS-SYSTEM; IN-VIVO; GROWTH-FACTOR; SPINAL-CORD; NEUROFIBROMATOSIS TYPE-1; HUMAN NEUROSPHERES; PRECURSOR CELLS; SELF-RENEWAL; BRAIN; PROLIFERATION;

D O I：

10.1101/gad.1988010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Neural stem and progenitor cells (NSCs) give rise to the cellular diversity of the CNS. There is evidence both for and against differences in these cells based on the region of the brain in which they reside. Primary brain tumors mimic many aspects of NSC behavior. Recent data suggest that some of the variability in glioma biology may be, in part, a reflection of regional differences in the NSCs from which they arise. In this issue of Genes & Development, Lee and colleagues ( pp. 2317-2329) examine how NF1 regulates NSC proliferation and glial differentiation in the brainstem and cortex of the postnatal mouse brain.

引用

页码：2233 / 2238

页数：6

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