Nitrofuran antibiotic metabolites detected at parts per million concentrations in retina of pigs - a new matrix for enhanced monitoring of nitrofuran abuse

被引:43
作者
Cooper, KM
Kennedy, DG
机构
[1] Dept Agr & Rural Dev, Vet Sci Div, Belfast BT4 3SD, Antrim, North Ireland
[2] Queens Univ Belfast, Dept Vet Sci, Belfast BT7 1NN, Antrim, North Ireland
关键词
D O I
10.1039/b418374f
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Nitrofuran metabolite residues AOZ, AMOZ, AHD and SEM were detected at parts per million concentrations in retina of pigs fed therapeutic doses of nitrofuran antibiotics. Discovery of this residue depot may allow widespread technology transfer to laboratories lacking LC-MS/MS thus improving global monitoring of these drugs.
引用
收藏
页码:466 / 468
页数:3
相关论文
共 12 条
[1]  
[Anonymous], 2003, OFF J EUR COMMUN L, VL71, P17
[2]   USE OF PIG HEPATOCYTES TO STUDY THE INHIBITION OF MONOAMINE-OXIDASE BY FURAZOLIDONE [J].
HOOGENBOOM, LAP ;
TOMASSINI, O ;
OORSPRONG, MBM ;
KUIPER, HA .
FOOD AND CHEMICAL TOXICOLOGY, 1991, 29 (03) :185-191
[3]   DEPLETION OF PROTEIN-BOUND FURAZOLIDONE METABOLITES CONTAINING THE 3-AMINO-2-OXAZOLIDINONE SIDE-CHAIN FROM LIVER, KIDNEY AND MUSCLE TISSUES FROM PIGS [J].
HOOGENBOOM, LAP ;
BERGHMANS, MCJ ;
POLMAN, THG ;
PARKER, R ;
SHAW, IC .
FOOD ADDITIVES AND CONTAMINANTS, 1992, 9 (06) :623-630
[4]   THE MELANIN BINDING OF DRUGS AND ITS IMPLICATIONS [J].
INGS, RMJ .
DRUG METABOLISM REVIEWS, 1984, 15 (5-6) :1183-1212
[5]   DRUG DISPOSITION IN THE MAMMALIAN EYE AND BRAIN - A COMPARISON OF MECHANISMS [J].
LEINWEBER, FJ .
DRUG METABOLISM REVIEWS, 1991, 23 (1-2) :133-246
[6]   Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography-tandem mass spectrometry [J].
Leitner, A ;
Zöllner, P ;
Lindner, W .
JOURNAL OF CHROMATOGRAPHY A, 2001, 939 (1-2) :49-58
[7]   TISSUE DISTRIBUTION AND RESIDUES OF CLENBUTEROL, SALBUTAMOL, AND TERBUTALINE IN TISSUES OF TREATED BROILER-CHICKENS [J].
MALUCELLI, A ;
ELLENDORFF, F ;
MEYER, HHD .
JOURNAL OF ANIMAL SCIENCE, 1994, 72 (06) :1555-1560
[8]   Determination of the furazolidone metabolite, 3-amino-2-oxazolidinone, in porcine tissues using liquid chromatography-thermospray mass spectrometry and the occurrence of residues in pigs produced in Northern Ireland [J].
McCracken, RJ ;
Kennedy, DG .
JOURNAL OF CHROMATOGRAPHY B, 1997, 691 (01) :87-94
[9]  
*NAT OFF AN HLTH L, 1992, COMP DAT SHEETS VET, P346
[10]  
Smith DJ, 2002, J ANIM SCI, V80, P2931