Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells

被引：103

作者：

Singh, F

Gao, DY

Lebwohl, MG

Wei, HC

机构：

[1] Mt Sinai Sch Med, Dept Dermatol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Community Med, New York, NY USA

来源：

CANCER LETTERS | 2003年 / 200卷 / 02期

关键词：

shikonin; human epidermoid carcinoma cells; epidermal growth factor receptor; protein tyrosine kinase; c-jun N-terminal kinase; ACTIVATED PROTEIN-KINASE; N-TERMINAL KINASE; LITHOSPERMUM-ERYTHRORHIZON; INDUCED APOPTOSIS; IN-VIVO; INDUCTION; GENE; ULTRAVIOLET; EXPRESSION; INGREDIENT;

D O I：

10.1016/S0304-3835(03)00239-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Shikonin isolated from the roots of the Chinese herb Lithospermum erythrorhizon has been associated with anti-inflammatory properties. We evaluated shikonin's chemotherapeutic potential and investigated its possible mechanism of action in a human cutaneous neoplasm in tissue culture. Shikonin preferentially inhibits the growth of human epidermoid carcinoma cells concentration- and time-dependently compared to SV-40 transfected keratinocytes, demonstrating its anti-proliferative effects against this cancer cell line. Additionally, shikonin decreased phosphorylated levels of EGFR, ERK1/2 and protein tyrosine kinases, while increasing phosphorylated JNK 1/2 levels. Overall, shikonin treatment was associated with increased intracellular levels of phosphorylated apoptosis-related proteins, and decreased levels of proteins associated with proliferation in human epidermoid carcinoma cells. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：115 / 121

页数：7

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