Galvanic vestibular stimulation reduces the pathological rightward line bisection error in neglect-A sham stimulation-controlled study

被引:52
作者
Utz, Kathrin S. [1 ,3 ]
Keller, Ingo [2 ]
Kardinal, Mareike [1 ,3 ]
Kerkhoff, Georg [1 ,3 ]
机构
[1] Univ Saarland, Clin Neuropsychol Unit, D-66123 Saarbrucken, Germany
[2] Schoen Clin Bad Aibling, Dept Neuropsychol, Bad Aibling, Germany
[3] Int Res Training Grp 1457 Adapt Minds, Saarbrucken, Germany
关键词
Neglect; Line bisection; Vestibular stimulation; Attention; Recovery; Neurotechnology; OPTOKINETIC STIMULATION; PRISM ADAPTATION; LASTING RECOVERY; HEMINEGLECT; IMPROVEMENT; DISTORTION; JUDGMENTS; DEFICIT; LESION; SAFETY;
D O I
10.1016/j.neuropsychologia.2011.02.046
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
Patients with right hemisphere lesions often show left spatial neglect and the typical rightward deviation in horizontal line bisection. Previous studies have shown that sensory stimulation modulates line bisection. A less well-known but promising sensory stimulation method is galvanic vestibular stimulation (GVS). This non-invasive technique leads to activation of the vestibular cortices and adjacent cortical areas in the temporo-parietal cortex via polarization effects of the vestibular nerves. This is accomplished by application of weak direct currents, delivered by two electrodes attached to the mastoids. Despite the relative benefits of GVS its effects on line bisection have not yet been studied in neglect patients. Thus, the present study investigated the impact of GVS on performance in a modified line bisection task in right-brain damaged patients with versus without leftsided visual neglect. In neglect patients, but not in control patients, left-cathodal and right-cathodal GVS significantly reduced the rightward line bisection error as compared to Baseline (without GVS) and sham stimulation. A larger decrease of the rightward line bisection error was observed during right-cathodal GVS. Sham stimulation showed no specific effects on line bisection. The beneficial effects of GVS might be due to activation of preserved structures of the lesioned right posterior parietal cortex which is known to be involved in line bisection. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1219 / 1225
页数:7
相关论文
共 40 条
[1]
[Anonymous], 1996, Neglect-test (NET)
[2]
Multisensory cortical signal increases and decreases during vestibular galvanic stimulation (fMRI) [J].
Bense, S ;
Stephan, T ;
Yousry, TA ;
Brandt, T ;
Dieterich, M .
JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (02) :886-899
[3]
The vestibular cortex - Its locations, functions, and disorders [J].
Brandt, T ;
Dieterich, M .
OTOLITH FUNCTION IN SPATIAL ORIENTATION AND MOVEMENT, 1999, 871 :293-312
[4]
Cerebral functional magnetic resonance imaging of vestibular, auditory, and nociceptive areas during galvanic stimulation [J].
Bucher, SF ;
Dieterich, M ;
Wiesmann, M ;
Weiss, A ;
Zink, R ;
Yousry, TA ;
Brandt, T .
ANNALS OF NEUROLOGY, 1998, 44 (01) :120-125
[5]
A NEWTONIAN MODEL OF PERCEPTUAL-DISTORTION IN VISUOSPATIAL NEGLECT [J].
BURNETTSTUART, G ;
HALLIGAN, PW ;
MARSHALL, JC .
NEUROREPORT, 1991, 2 (05) :255-257
[6]
BUTTER CM, 1990, RESTOR NEUROL NEUROS, V2, P39, DOI 10.3233/RNN-1990-2105
[7]
Causes of cross-over in unilateral neglect: between-group comparisons, within-patient dissociations and eye movements [J].
Doricchi, F ;
Guariglia, P ;
Figliozzi, F ;
Silvetti, M ;
Bruno, G ;
Gasparini, M .
BRAIN, 2005, 128 :1386-1406
[8]
Human vestibular cortex as identified with caloric stimulation in functional magnetic resonance imaging [J].
Fasold, O ;
von Brevern, M ;
Kuhberg, M ;
Ploner, CJ ;
Villringer, A ;
Lempert, T ;
Wenzel, R .
NEUROIMAGE, 2002, 17 (03) :1384-1393
[9]
Performing allocentric visuospatial judgments with induced distortion of the egocentric reference frame: an fMRI study with clinical implications [J].
Fink, GR ;
Marshall, JC ;
Weiss, PH ;
Stephan, T ;
Grefkes, C ;
Shah, NJ ;
Zilles, K ;
Dieterich, M .
NEUROIMAGE, 2003, 20 (03) :1505-1517
[10]
Right hemisphere control of visuospatial attention: line-bisection judgments evaluated with high-density electrical mapping and source analysis [J].
Foxe, JJ ;
McCourt, ME ;
Javitt, DC .
NEUROIMAGE, 2003, 19 (03) :710-726