Crystal structure of an intermolecular 2:1 complex between adenine and thymine. Evidence for both Hoogsteen and 'quasi-Watson-Crick' interactions

被引：18

作者：

Chandrasekhar, Sosale ^{[1
]}

Naik, Tangali R. Ravikumar ^{[1
]}

Nayak, Susanta K. ^{[1
,2
]}

Row, Tayur N. Guru ^{[2
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

[2] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期

关键词：

Adenine; Base pair; Hoogsteen; Thymine; Watson-Crick; X-ray diffraction; MOLECULAR-STRUCTURE; DYNAMICS; BASES;

D O I：

10.1016/j.bmcl.2010.04.131

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The titled complex, obtained by co-crystallization (EtOH/25 degrees C), is apparently the only known complex of the free bases. Its crystal structure, as determined by X-ray diffraction at both 90 K and 313 K, showed that one A-T pair involves a Hoogsteen interaction, and the other a Watson-Crick interaction but only with respect to the adenine unit. The absence of a clear-cut Watson-Crick base pair raises intriguing questions about the basis of the DNA double helix. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3530 / 3533

页数：4

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