Aziridination of styrene derivatives with 3-acetoxyaminoquinazolinones: probing transition state geometry from changes in diastereoselectivity

被引：13

作者：

Atkinson, RS ^{[1
]}

Claxton, TA ^{[1
]}

Lochrie, IST ^{[1
]}

Ulukanli, S ^{[1
]}

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 28期

关键词：

D O I：

10.1016/S0040-4039(98)00939-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In aziridinations of beta-substituted styrenes (4), (5) and (6) with the enantiopure 3-acetoxyaminoquinazolinone (1), diastereoselectivity (dr) increases from 5:1 for 6) to 10:1 (for (10) to similar to 20:1 (for (11)): changes in transition state geometry which account for this increase are rationalised using Frontier;Orbital Theory. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：5113 / 5116

页数：4

共 12 条

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