Inflammatory and thrombotic mechanisms in coronary atherosclerosis

被引:123
作者
Tousoulis, D
Davies, G
Stefanadis, C
Toutouzas, P
Ambrose, JA
机构
[1] Univ Athens, Sch Med, Cardiol Unit, Athens 16675, Greece
[2] Hammersmith Hosp, Cardiol Unit, London, England
[3] St Vincents Hosp & Med Ctr, Cardiol Unit, New York, NY 10011 USA
关键词
D O I
10.1136/heart.89.9.993
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Many molecular and cellular mechanisms link inflammation and haemostatic mechanisms. Inflammation, and perhaps chronic infection, may play important roles in the initiation and progression of atherosclerosis. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation (macrophages and T lymphocytes), and acute plaque rupture is also associated with inflammatory components. Several markers of systemic inflammation may predict future cardiovascular events in apparently healthy subjects as well as in patients with chronic and acute syndromes. There may thus be therapeutic potential in modifying the atherosclerotic, vasomotor, and thrombotic components of ischaemic heart disease.
引用
收藏
页码:993 / 997
页数:5
相关论文
共 86 条
[1]   Dietary lipid lowering reduces tissue factor expression in rabbit atheroma [J].
Aikawa, M ;
Voglic, SJ ;
Sugiyama, S ;
Rabkin, E ;
Taubman, MB ;
Fallon, JT ;
Libby, P .
CIRCULATION, 1999, 100 (11) :1215-1222
[2]   Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma - A potential mechanism of lesion stabilization [J].
Aikawa, M ;
Rabkin, E ;
Okada, Y ;
Voglic, SJ ;
Clinton, SK ;
Brinckerhoff, CE ;
Sukhova, GK ;
Libby, P .
CIRCULATION, 1998, 97 (24) :2433-2444
[3]  
Amberger A, 1997, CELL STRESS CHAPERON, V2, P94, DOI 10.1379/1466-1268(1997)002<0094:CEOIVE>2.3.CO
[4]  
2
[5]   Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection -: The azithromycin in coronary artery disease:: Elimination of myocardial infection with Chlamydia (ACADEMIC) study [J].
Anderson, JL ;
Muhlestein, JB ;
Carlquist, J ;
Allen, A ;
Trehan, S ;
Nielson, C ;
Hall, S ;
Brady, J ;
Egger, M ;
Horne, B ;
Lim, T .
CIRCULATION, 1999, 99 (12) :1540-1547
[6]   DIFFERENTIAL EXPRESSION OF TISSUE FACTOR PROTEIN IN DIRECTIONAL ATHERECTOMY SPECIMENS FROM PATIENTS WITH STABLE AND UNSTABLE CORONARY SYNDROMES [J].
ANNEX, BH ;
DENNING, SM ;
CHANNON, KM ;
SKETCH, MH ;
STACK, RS ;
MORRISSEY, JH ;
PETERS, KG .
CIRCULATION, 1995, 91 (03) :619-622
[7]   Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina -: Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes [J].
Aukrust, P ;
Müller, F ;
Ueland, T ;
Berget, T ;
Aaser, E ;
Brunsvig, A ;
Solum, NO ;
Forfang, K ;
Froland, SS ;
Gullestad, L .
CIRCULATION, 1999, 100 (06) :614-620
[9]   VIRUSES IN THE ETIOLOGY OF ATHEROSCLEROSIS [J].
BENDITT, EP ;
BARRETT, T ;
MCDOUGALL, JK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (20) :6386-6389
[10]   ATHEROSCLEROSIS - BASIC MECHANISMS - OXIDATION, INFLAMMATION, AND GENETICS [J].
BERLINER, JA ;
NAVAB, M ;
FOGELMAN, AM ;
FRANK, JS ;
DEMER, LL ;
EDWARDS, PA ;
WATSON, AD ;
LUSIS, AJ .
CIRCULATION, 1995, 91 (09) :2488-2496