On the selectivity of 7-nitroindazole as an inhibitor of neuronal nitric oxide synthase

被引:34
作者
Rainer, A [1 ]
Zagvazdin, Y [1 ]
机构
[1] Univ Tennessee, Dept Anat & Neurobiol, Memphis, TN 38163 USA
关键词
D O I
10.1016/S0165-6147(98)01194-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Not only neuronal nitric oxide synthase (NOS) but endothelial NOS is inhibited by 7-nitroindazole in vivo Copyright (C) 1998 Elsevier Science Ltd.
引用
收藏
页码:348 / 350
页数:3
相关论文
共 15 条
[1]  
CHOLET N, 1995, SOC NEUR ABSTR, V21
[2]   POTENTIATION OF NMDA-MEDIATED TOXICITY ON NIGROSTRIATAL NEURONS BY A LOW-DOSE OF 7-NITRO INDAZOLE [J].
CONNOP, BP ;
ROLFE, NG ;
BOEGMAN, RJ ;
JHAMANDAS, K ;
BENINGER, RJ .
NEUROPHARMACOLOGY, 1994, 33 (11) :1439-1445
[3]   NOS activity in brain and endothelium: Relation to hypercapnic rise of cerebral blood flow in rats [J].
Fabricius, M ;
Rubin, I ;
Bundgaard, M ;
Lauritzen, M .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1996, 271 (05) :H2035-H2044
[4]  
Harb HL, 1997, BRIT J PHARMACOL, V122, pP125
[5]   Modulation of ischemic excitatory neurotransmitter and gamma-aminobutyric acid release during global temporary cerebral ischemia by selective neuronal nitric oxide synthase inhibition [J].
Kahn, RA ;
Panah, M ;
Weinberger, J .
ANESTHESIA AND ANALGESIA, 1997, 84 (05) :997-1003
[6]   CHARACTERIZATION OF THE NOVEL NITRIC-OXIDE SYNTHASE INHIBITOR 7-NITRO INDAZOLE AND RELATED INDAZOLES - ANTINOCICEPTIVE AND CARDIOVASCULAR EFFECTS [J].
MOORE, PK ;
WALLACE, P ;
GAFFEN, Z ;
HART, SL ;
BABBEDGE, RC .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (01) :219-224
[7]   Selective inhibitors of neuronal nitric oxide synthase - Is no NOS really good NOS for the nervous system? [J].
Moore, PK ;
Handy, RLC .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1997, 18 (06) :204-211
[8]  
NAKAMURA K, 1993, ANESTH ANALG, V77, P877
[9]   Possible role of nitric oxide cyclic GMP pathway in object recognition memory: Effects of 7-nitroindazole and zaprinast [J].
Prickaerts, J ;
Steinbusch, HWM ;
Smits, JFM ;
deVente, J .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1997, 337 (2-3) :125-136
[10]  
TERASAKO K, 1994, ANESTH ANALG, V78, P823