Reconsidering targeted toxins to eliminate HIV infection: You gotta have HAART

被引：51

作者：

Berger, EA

Moss, B

Pastan, I

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

[2] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 20期

关键词：

D O I：

10.1073/pnas.95.20.11511

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The success of highly active anti-retroviral therapy (HAART) has inspired new concepts for eliminating HIV from infected individuals. A major obstacle is the persistence of long-lived reservoirs of latently infected cells that might become activated at some time after cessation of therapy. We propose that, in the context of treatment strategies to deliberately activate and eliminate these reservoirs, hybrid toxins targeted to kill HIV-infected cells be reconsidered in combination with HAART. Such combinations might also prove valuable in protocols aimed at preventing mother-to-child transmission and establishment of infection immediately after exposure to HIV. We suggest experimental approaches in vitro and in animal models to test various issues related to safety and efficacy of this concept.

引用

收藏

页码：11511 / 11513

页数：3

相关论文

共 33 条

[1] ELIMINATION OF INFECTIOUS HUMAN-IMMUNODEFICIENCY-VIRUS FROM HUMAN T-CELL CULTURES BY SYNERGISTIC ACTION OF CD4-PSEUDOMONAS EXOTOXIN AND REVERSE-TRANSCRIPTASE INHIBITORS [J].

ASHORN, P ;

MOSS, B ;

WEINSTEIN, JN ;

CHAUDHARY, VK ;

FITZGERALD, DJ ;

PASTAN, I ;

BERGER, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8889-8893

[2] ANTI-HIV ACTIVITY OF CD4-PSEUDOMONAS EXOTOXIN ON INFECTED PRIMARY HUMAN-LYMPHOCYTES AND MONOCYTE MACROPHAGES [J].

ASHORN, P ;

ENGLUND, G ;

MARTIN, MA ;

MOSS, B ;

BERGER, EA .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (04) :703-709

[3]

ASHORN P, 1992, J ACQ IMMUN DEF SYND, V5, P70

[4] RECOMBINANT CD4-PSEUDOMONAS EXOTOXIN HYBRID PROTEIN DISPLAYS HIV-SPECIFIC CYTOTOXICITY WITHOUT AFFECTING MHC CLASS-II-DEPENDENT FUNCTIONS [J].

BERGER, EA ;

CHAUDHARY, VK ;

CLOUSE, KA ;

JARAQUEMADA, D ;

NICHOLAS, JA ;

RUBINO, KL ;

FITZGERALD, DJ ;

PASTAN, I ;

MOSS, B .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (06) :795-804

[5] CD4-PSEUDOMONAS EXOTOXIN HYBRID PROTEIN BLOCKS THE SPREAD OF HUMAN IMMUNODEFICIENCY VIRUS-INFECTION INVITRO AND IS ACTIVE AGAINST CELLS EXPRESSING THE ENVELOPE GLYCOPROTEINS FROM DIVERSE PRIMATE IMMUNODEFICIENCY RETROVIRUSES [J].

BERGER, EA ;

CLOUSE, KA ;

CHAUDHARY, VK ;

CHAKRABARTI, S ;

FITZGERALD, DJ ;

PASTAN, I ;

MOSS, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9539-9543

[6] SELECTIVE KILLING OF HIV-INFECTED CELLS BY RECOMBINANT HUMAN CD4-PSEUDOMONAS EXOTOXIN HYBRID PROTEIN [J].

CHAUDHARY, VK ;

MIZUKAMI, T ;

FUERST, TR ;

FITZGERALD, DJ ;

MOSS, B ;

PASTAN, I ;

BERGER, EA .

NATURE, 1988, 335 (6188) :369-372

[7] Envelope glycoproteins of human immunodeficiency virus type 1: Profound influences on immune functions [J].

Chirmule, N ;

Pahwa, S .

MICROBIOLOGICAL REVIEWS, 1996, 60 (02) :386-+

[8] IN-VIVO FATE OF HIV-1-INFECTED T-CELLS - QUANTITATIVE-ANALYSIS OF THE TRANSITION TO STABLE LATENCY [J].

CHUN, TW ;

FINZI, D ;

MARGOLICK, J ;

CHADWICK, K ;

SCHWARTZ, D ;

SILICIANO, RF .

NATURE MEDICINE, 1995, 1 (12) :1284-1290

[9] Quantification of latent tissue reservoirs and total body viral load in HIV-1 Infection [J].

Chun, TW ;

Carruth, L ;

Finzi, D ;

Shen, XF ;

DiGiuseppe, JA ;

Taylor, H ;

Hermankova, M ;

Chadwick, K ;

Margolick, J ;

Quinn, TC ;

Kuo, YH ;

Brookmeyer, R ;

Zeiger, MA ;

BarditchCrovo, P ;

Siliciano, RF .

NATURE, 1997, 387 (6629) :183-188

[10] Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy [J].

Chun, TW ;

Stuyver, L ;

Mizell, SB ;

Ehler, LA ;

Mican, JAM ;

Baseler, M ;

Lloyd, AL ;

Nowak, MA ;

Fauci, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) :13193-13197

← 1 2 3 4 →