L-Asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia

被引：41

作者：

Sahu, S ^{[1
]}

Saika, S ^{[1
]}

Pai, SK ^{[1
]}

Advani, SH ^{[1
]}

机构：

[1] Tata Mem Hosp, Dept Med Oncol, Mumbai 400012, India

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1998年 / 15卷 / 06期

关键词：

acute lymphoblastic leukemia; childhood; L-asparaginase; pancreatitis;

D O I：

10.3109/08880019809018315

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A major complication of L-asparaginase therapy in acute lymphoblastic leukemia (ALL) is pancreatitis. Among the 915 cases of ALL seen over last 10 years, 19 (2 %) developed pancreatitis. Median age was 5.5 years with a median duration of symptoms of 4 weeks. All cases had raised serum amylase and lipase. Pancreatitis was not related to the dose/duration of L-asparaginase therapy. Ultrasonography can be used as a corroborative investigation for diagnosis along with serum chemistries. Close clinical monitoring of children for early diagnosis of this complication is recommended.

引用

页码：533 / 538

页数：6

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