Leptin deficiency suppresses progression of atherosclerosis in apoE-deficient mice

被引：61

作者：

Chiba, Tsuyoshi ^{[1
,3
]}

Shinozaki, Shohei ^{[1
]}

Nakazawa, Toru ^{[1
]}

Kawakami, Akio ^{[1
]}

Ai, Masumi ^{[1
]}

Kaneko, Eiji ^{[1
]}

Kitagawa, Masanobu ^{[2
]}

Kondo, Kazuo ^{[3
]}

Chait, Alan ^{[4
]}

Shimokado, Kentaro ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Grad Sch, Dept Med, Bunkyo Ku, Tokyo 1138519, Japan

[2] Tokyo Med & Dent Univ, Grad Sch, Dept Pathol, Bunkyo Ku, Tokyo 1138519, Japan

[3] Ochanomizu Univ, Inst Environm Sci Human Life, Bunkyo Ku, Tokyo 1128610, Japan

[4] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USA

来源：

ATHEROSCLEROSIS | 2008年 / 196卷 / 01期

关键词：

leptin; atherosclerosis; obesity; ob/ob mice; apoE(-/-) mice;

D O I：

10.1016/j.atherosclerosis.2007.01.040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both experimental and epidemiological studies suggest that leptin is one of the molecules responsible for accelerated atherosclerosis in obese humans. To confirm the notion, we studied whether leptin accelerates atherosclerosis in apoE(-/-) mice. Leptin deficient hyperlipidemic mice (ob/ob;apoE(-/-) mice) developed significantly less atherosclerosis than apoE(-/-) mice, when fed an atherogenic diet for 16 weeks from 8 weeks of age. Histological analysis revealed that most of the atherosclerotic lesions in ob/ob;apoE(-/-) mice remained as fatty streaks, while those in apoE(-/-) mice were mainly fibrous plaques. The decrease in atherosclerosis was not due to changes in the serum levels of cholesterol, TNF-alpha, or adiponectin. Exogenous leptin significantly increased atherosclerotic areas in apoE(-/-) mice, even though it decreased food intake and body weight. Our findings support the notion that leptin accelerates atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：68 / 75

页数：8

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