A highly effective phosphinite ligand derived from D-mannitol for Rh-catalyzed asymmetric hydrogenation

被引：46

作者：

Chen, YX

Li, XS

Tong, SK

Choi, MCK

Chan, ASC ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Union Lab Asymmetr Synth, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

rhodium; asymmetric hydrogenation; D-mannitol; phosphinite; alpha-amidoacrylic acid;

D O I：

10.1016/S0040-4039(98)02457-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel chiral phosphinite 1,2, 5,6-di-isopropylidene-3,4-bis(diphenylphosphino)-D-mannitol was prepared and its rhodium complex was found to be an effective catalyst for the asymmetric hydrogenation of amidoacrylic acid and its derivatives with product ee's ranging from 90% to 97%. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：957 / 960

页数：4

共 7 条

[1]

BOSNICH B, 1986, ASYMMETRIC CATALYSIS, P19

[2]

BRUNNER H, 1988, SYNTHESIS-STUTTGART, P645

[3] Novel spiro phosphinite ligands and their application in homogeneous catalytic hydrogenation reactions [J].