Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal

被引：215

作者：

Cohen, Ethan David ^{[1
,2
]}

Tian, Ying ^{[1
,2
]}

Morrisey, Edward E. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

DEVELOPMENT | 2008年 / 135卷 / 05期

关键词：

D O I：

10.1242/dev.016865

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Emerging evidence indicates that Wnt signaling regulates crucial aspects of cardiovascular biology (including cardiac morphogenesis, and the self-renewal and differentiation of cardiac progenitor cells). The ability of Wnt signaling to regulate such diverse aspects of cardiovascular development rests on the multifarious downstream and tangential targets affected by this pathway. Here, we discuss the roles for Wnt signaling in cardiac and vascular development, and focus on the emerging role of Wnt signaling in cardiovascular morphogenesis and progenitor cell self-renewal.

引用

页码：789 / 798

页数：10

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