NMDA-induced intrinsic voltage oscillations depend on L-type calcium channels in spinal motoneurons of adult turtles

被引:53
作者
Guertin, PA [1 ]
Hounsgaard, J [1 ]
机构
[1] Univ Copenhagen, Panum Inst, Dept Med Physiol, Div Neurophysiol, DK-2200 Copenhagen N, Denmark
关键词
D O I
10.1152/jn.1998.80.6.3380
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In a slice preparation from adult turtles, bath-applied N-methyl-D-aspartate (NMDA) induced rhythmic activity in spinal motoneurons. The underlying intrinsic oscillation in membrane potential was revealed in the presence of tetrodotoxin (TTX). NMDA-induced rhythmicity, in the presence or absence of TTX, was abolished or reduced by NMDA receptor antagonists and by three different classes of antagonists for L-type calcium channels. It is suggested that both NMDA receptor channels and L-type calcium channels contribute to NMDA-induced intrinsic oscillations in mature spinal motoneurons.
引用
收藏
页码:3380 / 3382
页数:3
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