Treatment of refractory delayed onset heparin-induced thrombocytopenia after thoracic endovascular aortic repair with intravenous immunoglobulin (IVIG)

被引：19

作者：

Doucette, Kimberley ^{[1
]}

DeStefano, Christin B. ^{[2
]}

Jain, Natasha A. ^{[1
]}

Cruz, Allan L. ^{[2
]}

Malkovska, Vera ^{[2
]}

Fitzpatrick, Kelly ^{[2
]}

机构：

[1] Medstar Washington Hosp Ctr, Dept Internal Med, Washington, DC 20010 USA

[2] Medstar Washington Hosp Ctr, Dept Hematol Oncol, Washington, DC USA

来源：

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | 2017年 / 1卷 / 01期

关键词：

heparin; immunoglobulins; intravenous; thrombocytopenia; thrombosis;

D O I：

10.1002/rth2.12009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Delayed onset heparin induced thrombocytopenia (HIT), is characterized by a late nadir due to persistent platelet-activating IgG antibodies. It typically begins or worsens 5 or more days after heparin is discontinued with complications such as thrombosis up to 3 weeks after exposure to heparin.(1-3) In 50% of cases, the platelet count can decrease to very low numbers (<20 000/mu L), which is not usual for typical HIT. Here we report 2 cases of post-operative delayed onset HIT manifesting as severe thrombocytopenia that persisted despite cessation of heparin and initiation of argatroban. Key Clinical Question: Is intravenous immunoglulin beneficial in severe refractory delayed-onset HIT?

引用

页码：134 / 137

页数：4

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