Spliceosome mutations in hematopoietic malignancies

被引：45

作者：

Hahn, Christopher N. ^{[1
]}

Scott, Hamish S. ^{[1
]}

机构：

[1] SA Pathol Adelaide, Ctr Canc Biol, Dept Mol Pathol, Adelaide, SA, Australia

来源：

NATURE GENETICS | 2012年 / 44卷 / 01期

关键词：

D O I：

10.1038/ng.1045

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies, including two in this issue, report heterozygous missense mutations in the U2AF1 and SF3B1 genes that encode spliceosome subunits. U2AF1 is frequently mutated in myeloid hematopoietic malignancies, especially in myelodysplastic syndrome (MDS), and SF3B1 is frequently mutated in both MDS and chronic lymphocytic leukemia (CLL).

引用

页码：9 / 10

页数：2

共 13 条

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