The Role of p66shc in Oxidative Stress and Apoptosis

被引：111

作者：

Galimov, E. R. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Belozersky Inst Physicochem Biol, Moscow, Russia

来源：

ACTA NATURAE | 2010年 / 2卷 / 04期

关键词：

apoptosis; reactive oxygen species; p66shc; mitochondria; LIFE-SPAN; ADAPTER PROTEIN; CYTOCHROME-C; FORKHEAD PROTEINS; GENETIC DELETION; P66(SHC) GENE; CELL-DEATH; PHOSPHORYLATION; REGULATOR; SURVIVAL;

D O I：

10.32607/20758251-2010-2-4-44-51

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

p66shc is a gene that regulates the level of reactive oxygen species (ROS), apoptosis induction, and lifespan in mammals. Mice knocked out for p66shc have a lifespan similar to 30% longer and demonstrate an enhanced resistance to oxidative stress and age-related pathologies such as hypercholesterolemia, ischemia, and hyperglycemia. In this respect, p66shc is a promising pharmacological target for the treatment of age-related diseases. In this review, an attempt has been made to survey and put to a critical analysis data concerning the involvement of p66shc in the different signaling pathways that regulate oxidative stress and apoptosis.

引用

页码：44 / 51

页数：8

共 58 条

[1]

Oxidative Stress Stimulates Apoptosis and Activates NF-κB in Osteoblastic Cells via a PKCβ/p66shc Signaling Cascade: Counter Regulation by Estrogens or Androgens [J].

Almeida, Maria ;

Han, Li ;

Ambrogini, Elena ;

Bartell, Shoshana M. ;

Manolagas, Stavros C. .

MOLECULAR ENDOCRINOLOGY, 2010, 24 (10) :2030-2037

[2]

p66shc inhibits pro-survival epidermal growth factor receptor/ERK signaling during severe oxidative stress in mouse renal proximal tubule cells [J].

Arany, Istvan ;

Faisal, Amir ;

Nagamine, Yoshikuni ;

Safirstein, Robert L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (10) :6110-6117

[3]

p66Shc-generated Oxidative Signal Promotes Fat Accumulation [J].

Berniakovich, Ina ;

Trinei, Mirella ;

Stendardo, Massimo ;

Migliaccio, Enrica ;

Minucci, Saverio ;

Bernardi, Paolo ;

Pelicci, Pier Giuseppe ;

Giorgio, Marco .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (49) :34283-34293

[4]

Genetic deletion of p66Shc adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress [J].

Camici, Giovanni G. ;

Schiavoni, Marzia ;

Francia, Pietro ;

Bachschmid, Markus ;

Martin-Padura, Ines ;

Hersberger, Martin ;

Tanner, Felix C. ;

Pelicci, PierGiuseppe ;

Volpe, Massimo ;

Anversa, Piero ;

Luescher, Thomas F. ;

Cosentino, Francesco .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (12) :5217-5222

[5]

p66Shc is involved in promoting HIF-1α accumulation and cell death in hypoxic T cells [J].

Carraro, Fabio ;

Pucci, Annalisa ;

Pellegrini, Michela ;

Pelicci, Pier Giuseppe ;

Baldari, Cosima T. ;

Naldini, Antonella .

JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 211 (02) :439-447

[6]

Chaladi A., 2008, MOL BIOL CELL, V19, P2609

[7]

p66ShcA modulates oxidative stress and survival of endothelial progenitor cells in response to high glucose [J].

Di Stefano, Valeria ;

Cencioni, Chiara ;

Zaccagnini, Germana ;

Magenta, Alessandra ;

Capogrossi, Maurizio C. ;

Martelli, Fabio .

CARDIOVASCULAR RESEARCH, 2009, 82 (03) :421-429

[8]

RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas [J].

Fagiani, Ernesta ;

Giardina, Giuseppina ;

Luzi, Lucilla ;

Cesaroni, Matteo ;

Quarto, Micaela ;

Capra, Maria ;

Germano, Giovanni ;

Bono, Maria ;

Capillo, Manuela ;

Pelicci, PierGiuseppe ;

Lanfrancone, Luisa .

CANCER RESEARCH, 2007, 67 (07) :3064-3073

[9]

Serine/threonine phosphorylation of ShcA - Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling [J].

Faisal, A ;

El-Shemerly, M ;

Hess, D ;

Nagamine, Y .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :30144-30152

[10]

Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells [J].

Foschi, M ;

Franchi, F ;

Han, JH ;

La Villa, G ;

Sorokin, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (28) :26640-26647

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