Identification of hippocampus-related candidate genes for Alzheimer's disease

被引：36

作者：

Taguchi, K

Yamagata, HD ^{[1
]}

Zhong, WT

Kamino, K

Akatsu, H

Hata, R

Yamamoto, T

Kosaka, K

Takeda, M

Kondo, I

Miki, T

机构：

[1] Natl Univ Corp, Ehime Univ, Sch Med, Dept Med Genet, Touon, Ehime 7910295, Japan

[2] Natl Univ Corp, Ehime Univ, Sch Med, Dept Geriatr Med, Touon, Ehime 7910295, Japan

[3] Osaka Univ, Grad Sch Med, Div Psychiat & Behav Proteom, Dept Post Genom & Dis, Suita, Osaka, Japan

[4] Fukushimura Hosp, Choju Med Inst, Toyohashi, Aichi, Japan

[5] Natl Univ Corp, Ehime Univ, Sch Med, Div Funct Histol, Touon, Ehime 7910295, Japan

来源：

ANNALS OF NEUROLOGY | 2005年 / 57卷 / 04期

关键词：

D O I：

10.1002/ana.20433

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a complex multifactorial disease in which many genetic and environmental factors are involved. We performed an association study using 376 AD patients and 376 control subjects. We studied 35 single nucleotide polymorphisms in 35 genes that were significantly downregulated or upregulated only in the AD hippocampus compared with control and found that 9 single nucleotide polymorphisms were associated with AD. Our data indicated that single nucleotide polymorphisms could highly reflect differences in gene expression. Furthermore, an intronic polymorphism. (+9943T/C) in POU2F1 was most significantly associated with AD (p = 0.0007). Our results suggest that POU2F1 is a candidate gene for AD.

引用

页码：585 / 588

页数：4

共 17 条

[1]

[Anonymous], ALZHEIMERS DIS

[2] PHENOTYPIC HETEROGENEITY IN FAMILIAL ALZHEIMERS-DISEASE - A STUDY OF 24 KINDREDS [J].