Substrate specificity for catalysis of phosphodiester cleavage by a dinuclear Zn(II) complex

被引：56

作者：

Yang, MY ^{[1
]}

Richard, JP ^{[1
]}

Morrow, JR ^{[1
]}

机构：

[1] SUNY Buffalo, Dept Chem, Buffalo, NY 14260 USA

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 22期

关键词：

D O I：

10.1039/b308644e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 2.4 kcal mol(-1) greater stabilization of the transition state for cleavage of the minimal substrate HpPNP compared to the nucleoside substrate UpPNP by the efficient dinuclear metal ion catalyst Zn-2(L2O) provides evidence that access to the cationic core of Zn-2(L2O) is sterically blocked for the bulkier nucleoside substrates, a flaw that will need to be dealt with in later generations of metal ion catalysts of RNA cleavage.

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页码：2832 / 2833

页数：2

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