Interleukin-6 levels are not increased in women with postpartum thyroid dysfunction

被引:14
作者
Ahmad, L
Parkes, A
Lazarus, J
Bartalena, L
Martin, E
Diamond, E
Stagnaro-Green, A
机构
[1] CUNY Mt Sinai Sch Med, Dept Med, Div Endocrinol & Metab, New York, NY 10029 USA
[2] Cardiff Univ, Dept Med, Cardiff CF4 4XN, S Glam, Wales
[3] Univ Pisa, Ist Endocrinol, Pisa, Italy
关键词
D O I
10.1089/thy.1998.8.371
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Postpartum thyroid dysfunction (PPTD) is an autoimmune-mediated thyroid destructive process. Human interleukin-6 (IL-6) is a cytokine found to be increased in subacute thyroiditis, amiodarone-induced thyrotoxicosis, Graves' disease, and other thyroid destructive processes. We report serum IL-6 levels in PPTD in two independent studies. New York Study: In a previous prospective study we demonstrated that PPTD occurred in 25% (7/28) of women with type 1 diabetes mellitus. IL-6 determinations were made on the frozen serum samples of these 28 women during each trimester of their pregnancy and at 1.5, 3, 6, 9, and 12 months postpartum. IL-6 levels were found to be similar in women with PPTD compared with women without PPTD (mean 3.06 +/- 2.25 vs. 2.51 +/- 2.21 pg/mL; P = 0.15). No difference in IL-6 levels was found between the pre-and the postpartum periods (mean 2.67 +/- 1.82 vs. 3.04 +/- 2.44 pg/mL; p = 0.30) in all 28 women. Cardiff Study: Serum IL-6 levels were measured on frozen serum samples of 30 women with PPTD. IL-6 levels were below the detection limit (25 fmol/L or 0.65 pg/mL) in 94 (67%) of these samples. No significant difference in the mean serum IL-6 levels were found between any time points in the study. There was no correlation between serum IL-6 levels, thyroid peroxidase (TPO)-antibodies and serum thyrotropin (TSH) levels at any time point. IL-6 levels during pregnancy or postpartum were not found to be significantly different in women with PPTD compared with women without PPTD.
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页码:371 / 375
页数:5
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