Plasma dehydroepiandrosterone sulfate in unipolar major depression

被引：118

作者：

Takebayashi, M

Kagaya, A

Uchitomi, Y

Kugaya, A

Muraoka, M

Yokota, N

Horiguchi, J

Yamawaki, S

机构：

[1] Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Minami Ku, Hiroshima 7348551, Japan

[2] Natl Canc Ctr, Res Inst E, Psychooncol Div, Kashiwa, Chiba, Japan

来源：

JOURNAL OF NEURAL TRANSMISSION | 1998年 / 105卷 / 4-5期

关键词：

dehydroepiandrosterone sulfate; depression;

D O I：

10.1007/s007020050077

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated plasma dehydroepiandrosterone sulfate (DHEAS) and cortisol levels in 12 patients with unipolar depression and 11 matched normal controls. The depressed patients showed significantly higher values of plasma DHEAS and cortisol than the controls. After 4 weeks of treatment with antidepressants (mainly clomiplamine), the high plasma DHEAS levels recovered. This finding showed the possible relationship between plasma DHEAS levels and depression, as well as cortisol levels.

引用

页码：537 / 542

页数：6

共 22 条

[1]

[Anonymous], 1987, DIAGNOSTIC STAT MANU, V4th

[2]

BAULIEU EE, 1992, ADV BIOCHEM PSYCHOPH, V47, P1

[3]

HIGH, USUAL AND IMPAIRED FUNCTIONING IN COMMUNITY-DWELLING OLDER MEN AND WOMEN - FINDINGS FROM THE MACARTHUR FOUNDATION RESEARCH NETWORK ON SUCCESSFUL AGING [J].

BERKMAN, LF ;

SEEMAN, TE ;

ALBERT, M ;

BLAZER, D ;

KAHN, R ;

MOHS, R ;

FINCH, C ;

SCHNEIDER, E ;

COTMAN, C ;

MCCLEARN, G ;

NESSELROADE, J ;

FEATHERMAN, D ;

GARMEZY, N ;

MCKHANN, G ;

BRIM, G ;

PRAGER, D ;

ROWE, J .

JOURNAL OF CLINICAL EPIDEMIOLOGY, 1993, 46 (10) :1129-1140

[4]

CARROLL BJ, 1976, HORMONES BEHAV PSYCH

[5]

FAVA M, 1988, Psychiatry Research, V28, P345

[6]

PRELIMINARY INVESTIGATION OF STEROID EXCRETION IN DEPRESSED PATIENTS BEFORE + AFTER ELECTRO-CONVULSIVE THERAPY [J].

FERGUSON, HC ;

CATHRO, DM ;

BARTRAM, ACG ;

BIRCHALL, K ;

FOWLIE, HC ;

MITCHELL, FL .

ACTA ENDOCRINOLOGICA, 1964, 47 (01) :58-&

[7]

GLASSMAN AH, 1987, AM J PSYCHIAT, V144, P1253

[8]

Adrenal secretion during major depression in 8- to 16-year-olds .1. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation [J].

Goodyer, IM ;

Herbert, J ;

Altham, PME ;

Pearson, J ;

Secher, SM ;

Shiers, HM .

PSYCHOLOGICAL MEDICINE, 1996, 26 (02) :245-256

[9]

A RATING SCALE FOR DEPRESSION [J].

HAMILTON, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62

[10]

HANSEN CR, 1982, AM J PSYCHIAT, V139, P386

← 1 2 3 →