Statin-mediated inhibition of Rho - Only to get more NO?

被引:15
作者
Brandes, RP [1 ]
机构
[1] Univ Frankfurt, Fachbereich Med, Inst Kardiovaskulaire Physiol, D-60596 Frankfurt, Germany
关键词
statins; nitric oxide; endothelium; GTPases; hypertension;
D O I
10.1161/01.RES.0000168040.70096.2a
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:927 / 929
页数:3
相关论文
共 19 条
[1]   Transient and prolonged increase in endothelial permeability induced by histamine and thrombin -: Role of protein kinases, calcium, and RhoA [J].
Amerongen, GPV ;
Draijer, R ;
Vermeer, MA ;
van Hinsbergh, VWM .
CIRCULATION RESEARCH, 1998, 83 (11) :1115-1123
[2]   Active Rho kinase (ROK-α) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells [J].
Begum, N ;
Sandu, OA ;
Ito, M ;
Lohmann, SM ;
Smolenski, A .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (08) :6214-6222
[3]   Rho and Rac take center stage [J].
Burridge, K ;
Wennerberg, K .
CELL, 2004, 116 (02) :167-179
[4]   Thrombin suppresses endothelial nitric oxide synthase and upregulates endothelin-converting enzyme-1 expression by distinct pathways -: Role of Rho/ROCK and mitogen-activated protein kinase [J].
Eto, M ;
Barandiér, C ;
Rathgeb, L ;
Kozai, T ;
Joch, H ;
Yang, ZH ;
Lüscher, TF .
CIRCULATION RESEARCH, 2001, 89 (07) :583-590
[5]   Statin pleiotropy: Fact or fiction? [J].
Futterman, LG ;
Lemberg, L .
AMERICAN JOURNAL OF CRITICAL CARE, 2004, 13 (03) :244-249
[6]   Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by rho GTPase [J].
Laufs, U ;
Liao, JK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) :24266-24271
[7]   Cell-penetrating peptides [J].
Lindgren, M ;
Hallbrink, M ;
Prochiantz, A ;
Langel, U .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2000, 21 (03) :99-103
[8]   Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans [J].
Masumoto, A ;
Hirooka, Y ;
Shimokawa, H ;
Hironaga, K ;
Setoguchi, S ;
Takeshita, A .
HYPERTENSION, 2001, 38 (06) :1307-1310
[9]   Clinical review 145 - Pleiotropic effects of statins: Lipid reduction and beyond [J].
McFarlane, SI ;
Muniyappa, R ;
Francisco, R ;
Sowers, JR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (04) :1451-1458
[10]   Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells [J].
Ohkawara, H ;
Ishibashi, T ;
Sakamoto, T ;
Sugimoto, K ;
Nagata, K ;
Yokoyama, K ;
Sakamoto, N ;
Kamioka, M ;
Matsuoka, I ;
Fukuhara, S ;
Sugimoto, N ;
Takuwa, Y ;
Maruyama, Y .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (11) :10182-10188