The first-line use of vigabatrin to achieve complete control of infantile spasms

被引：8

作者：

Covanis, A ^{[1
]}

Theodorou, V ^{[1
]}

Lada, C ^{[1
]}

Skiadas, K ^{[1
]}

Loli, N ^{[1
]}

机构：

[1] Aghia Sophia Childrens Hosp, Dept Neurol, Athens 11527, Greece

来源：

JOURNAL OF EPILEPSY | 1998年 / 11卷 / 05期

关键词：

infantile spasms; west; syndrome; monotherapy; vigabatrin; efficacy; first-line therapy;

D O I：

10.1016/S0896-6974(98)00030-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Vigabatrin was given as first-line therapy in 29 children with infantile spasms (IS). Vigabatrin monotherapy achieved complete control of spasms without subsequent relapse in 45% of patients. In all other patients, response was partial or relapse occurred, and in these patients add-on therapy with tetra-cosactrin and/or clonazepam achieved a complete response. Side-effects with vigabatrin were mild and transient, and occurred in only four patients. The complete responses observed with vigabatrin occurred a short time after initiating treatment. These data further support the high efficacy of vigabatrin as first-line monotherapy for the treatment of IS. (C) 1998 by Elsevier Science Inc. All rights reserved.

引用

页码：265 / 269

页数：5

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