New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice

被引：71

作者：

Kimura, I

Yoshikawa, M

Kobayashi, S

Sugihara, Y

Suzuki, M

Oominami, H

Murakami, T

Matsuda, H

Doiphode, VV

机构：

[1] Toyama Med & Pharmaceut Univ, Grad Sch Pharmaceut Sci, Dept Clin Pharmacol, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, Toyama 9300194, Japan

[3] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan

[4] Hokuriku Univ, Fac Pharmaceut Sci, Dept Pharmacol, Kanazawa, Ishikawa 9201181, Japan

[5] Univ Pune, Ayurvedic Fac, Poona 411011, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(01)00111-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or Commiphora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect on exudative pouch fluid, angiogenesis, and granuloma weights in adjuvant-induced air-pouch granuloma of mice. Its effects were more marked than those of hydrocortisone and the 50% aqueous methanolic extract of the crude drug. Myrrhanol A is a plausible candidate for a potent anti-inflammatory agent. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：985 / 989

页数：5

共 13 条

[1]

ARORA RB, 1972, INDIAN J MED RES, V60, P929

[2]

Beg M., 1996, Indian Journal of Physiology and Pharmacology, V40, P237

[3]

Chander R, 1996, PHYTOTHER RES, V10, P508, DOI 10.1002/(SICI)1099-1573(199609)10:6&lt

[4]

508::AID-PTR895&gt

[5]

3.0.CO

[6]

2-P

[7] Analgesic effects of myrrh [J].

Dolara, P ;

Luceri, C ;

Ghelardini, C ;

Monserrat, C ;

Aiolli, S ;

Luceri, F ;

Lodovici, M ;

Menichetti, S ;

Romanelli, MN .

NATURE, 1996, 379 (6560) :29-29

[8] ANTIINFLAMMATORY ACTIVITY OF RESINS FROM SOME SPECIES OF THE PLANT FAMILY BURSERACEAE [J].

DUWIEJUA, M ;

ZEITLIN, IJ ;

WATERMAN, PG ;

CHAPMAN, J ;

MHANGO, GJ ;

PROVAN, GJ .

PLANTA MEDICA, 1993, 59 (01) :12-16

[9] SELECTIVE-INHIBITION BY MAGNOSALIN AND MAGNOSHININ, COMPOUNDS FROM SHIN-I (FLOS-MAGNOLIAE), OF ADJUVANT-INDUCED ANGIOGENESIS AND GRANULOMA-FORMATION IN THE MOUSE POUCH [J].

KIMURA, M ;

KOBAYASHI, S ;

LUO, B ;

KIMURA, I .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1990, 93 (04) :365-370

[10] QUANTITATIVE METHOD FOR MEASURING ADJUVANT-INDUCED GRANULOMA ANGIOGENESIS IN INSULIN-TREATED DIABETIC MICE [J].

KIMURA, M ;

AMEMIYA, K ;

YAMADA, T ;

SUZUKI, J .

JOURNAL OF PHARMACOBIO-DYNAMICS, 1986, 9 (05) :442-446

← 1 2 →