Antiepileptic drug use in nursing home residents: Effect of age, gender, and comedication on patterns of use

被引:86
作者
Lackner, TE
Cloyd, JC
Thomas, LW
Leppik, IE
机构
[1] Univ Minnesota, PharMerica, Minneapolis, MN USA
[2] Univ Minnesota, Coll Pharm, Minneapolis, MN 55455 USA
[3] Univ Minnesota, MINCEP Epilepsy Care, Minneapolis, MN USA
[4] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA
关键词
antiepileptic; nursing home; age; gender; co-medication;
D O I
10.1111/j.1528-1157.1998.tb01294.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: Examine antiepileptic drug (AED) use in nursing homes by age, gender, and use of comedication that can interact with AEDs. Methods: Two point-prevalence evaluations of AED use from computerized medical records of nursing home residents throughout the United States (set 1, 43,757; set 2, 41,386) 65 years and older serviced by PHARMERICA. Results: 10.5% of residents received an AED. Of the age group 65-84 years, 15% received an AED compared with 6.1% of those 85 years or older (p < 0.001). Gender differences were present: 13.4% of the male residents and 9.4% of the female residents were treated with an AED (p < 0.001). The most frequently prescribed AEDs were phenytoin, carbamazepine, clonazepam, or phenobarbital. The average number of routine medications taken by AED recipients was 5.6, greater than the average of 4.6 for other residents. Conclusions: AEDs are extensively prescribed for elderly nursing home residents. Men and persons aged 65-85 years were more likely to receive AEDs than were women or those older than 85 years. AED recipients receive more routine medications than do other residents, including co-medications that alter hepatic metabolism and clinical response. The reasons for age and gender differences are unclear and require further study.
引用
收藏
页码:1083 / 1087
页数:5
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