A fuzzy mitochondrial fusion apparatus comes into focus

被引：102

作者：

Mozdy, AD ^{[1
]}

Shaw, JM ^{[1
]}

机构：

[1] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrm1125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Membrane fusion is fundamental to eukaryotic life. Unlike the predominant intracellular fusion machineries that fuse compartments bounded by a single membrane, the mitochondrial fusion machinery must sequentially fuse the outer and inner mitochondrial membranes. These coordinated fusion events rely on a transmembrane GTPase that is known as fuzzy onions or Fzo. Recent studies have revealed that Fzo has an evolutionarily conserved role in mitochondrial fusion, and they take the first strides in determining the molecular nature of such a role.

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页码：468 / 478

页数：11

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