Time-dependent behavioral recovery after pneumococcal meningitis in rats

被引：24

作者：

Barichello, Tatiana ^{[1
,2
,4
]}

Silva, Geruza Z. ^{[2
,4
]}

Generoso, Jaqueline S. ^{[2
,4
]}

Savi, Geovana D. ^{[2
,4
]}

Michelon, Cleonice M. ^{[2
,4
]}

Feier, Gustavo ^{[3
,4
]}

Comim, Clarissa M. ^{[3
,4
]}

Quevedo, Joao ^{[3
,4
,5
]}

机构：

[1] Univ Extremo Sul Catarinense, UNASAU, PPGCS, Lab Fisiopatol Expt, BR-88806000 Criciuma, SC, Brazil

[2] Univ So Santa Catarina, Microbiol Lab, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil

[3] Univ So Santa Catarina, Neurosci Lab, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil

[4] Univ So Santa Catarina, Natl Inst Translat Med, Postgrad Program Hlth Sci, Hlth Sci Unit, BR-88806000 Criciuma, SC, Brazil

[5] Hosp Sao Jose, Lab Translat Psychiat, Res Ctr, BR-88801250 Criciuma, SC, Brazil

来源：

JOURNAL OF NEURAL TRANSMISSION | 2010年 / 117卷 / 07期

关键词：

Learning; Memory; Depression; Anxiety; Central nervous system; Meningitis; AGGRAVATES HIPPOCAMPAL APOPTOSIS; BACTERIAL-MENINGITIS; LEARNING-DEFICITS; ADULTS; DEXAMETHASONE; SEQUELAE; THERAPY; INJURY; MEMORY;

D O I：

10.1007/s00702-010-0435-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alterations in hippocampus frequently occur following bacterial meningitis, despite antibiotic treatment. We investigated the cognitive performance in rats submitted to bacterial meningitis after 10, 30, and 60 days. To this aim, we utilized male Wistar rats submitted to either sham (control) or meningitis by Streptococcus pneumoniae, and followed by the initiation of the antibiotic treatment at 16 h after inoculation. The animals underwent six behavioral tasks 10, 30 and 60 days after surgery. We demonstrated that some of the learning and memory impairment, demonstrated 10 days after the induction of meningitis, persists up to 30 days, but not 60 days after induction.

引用

页码：819 / 826

页数：8

共 28 条

[1] Tumor necrosis factor alpha (TNF-α) levels in the brain and cerebrospinal fluid after meningitis induced by Streptococcus pneumoniae [J].