Roxithromycin inhibits cytokine production by and neutrophil attachment to human bronchial epithelial cells in vitro

被引：76

作者：

Kawasaki, S

Takizawa, H

Ohtoshi, T

Takeuchi, N

Kohyama, T

Nakamura, H

Kasama, T

Kobayashi, K

Nakahara, K

Morita, Y

Yamamoto, K

机构：

[1] Univ Tokyo, Sch Med, Dept Lab Med, Bunkyo Ku, Tokyo 113, Japan

[2] Univ Tokyo, Sch Med, Dept Med & Phys Therapy, Bunkyo Ku, Tokyo 113, Japan

[3] Univ Tokyo, Sch Med, Dept Otopharyngol, Bunkyo Ku, Tokyo 113, Japan

[4] Showa Univ, Sch Med, Dept Internal Med 1, Yamagata, Japan

[5] Natl Inst Infect Dis, Tokyo, Japan

[6] Yamagata Univ, Sch Med, Dept Internal Med 1, Yamagata 99023, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 06期

关键词：

D O I：

10.1128/AAC.42.6.1499

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the effect of roxithromycin on cytokine production and neutrophil attachment to human airway epithelial cells. Roxithromycin suppressed production of interleukin 8 (IL-8), IL-6, and granulocyte-macrophage colony-stimulating factor. It inhibited neutrophil adhesion to epithelial cells. Roxithromycin modulates local recruitment and activation of inflammatory cells, which may have relevance to its efficacy in airway diseases.

引用

页码：1499 / 1502

页数：4

共 20 条

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