Single molecule visualization of stable, stiffness-tunable, flow-conforming worm micelles

被引:96
作者
Dalhaimer, P
Bates, FS
Discher, DE [1 ]
机构
[1] Univ Penn, Dept Chem & Mol Engn, Philadelphia, PA 19104 USA
[2] Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA
关键词
D O I
10.1021/ma034120d
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
We describe fluorescence visualization of highly stable worm micelle superpolymers. The worm micelles are self-assembled in water from nonionic, block copolymer amphiphiles. By blending and polymerizing inert and cross-linkable copolymers, we form micelles up to tens of microns long with persistence lengths that continuously span more than 2 orders of magnitude from submicron to submillimeter. In flow, pristine worms orient and stretch with DNA-like scaling, and their stability, loading capacity, and stealthiness make them ideal candidates for flow-intensive delivery applications such as phage-mimetic drug carriers and micropore delivery.
引用
收藏
页码:6873 / 6877
页数:5
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