Quinupristin-dalfopristin resistance in Streptococcus pneumoniae:: Novel L22 ribosomal protein mutation in two clinical isolates from the SENTRY Antimicrobial Surveillance Program

被引：19

作者：

Jones, RN

Farrell, DJ

Morrissey, I

机构：

[1] JMI Labs Inc, JONES Grp, N Liberty, IA 52317 USA

[2] GR Micro Ltd, London, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 08期

关键词：

D O I：

10.1128/AAC.47.8.2696-2698.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistance to quinupristin-dalfopristin (Q/D) among gram-positive cocci has been very uncommon. Two clinical isolates among 8,837 (0.02%) Streptococcus pneumoniae isolates were discovered in 2001 to 2002 with Q/D MICs of 4 mug/ml. Each had a 5-amino-acid tandem duplication (RTAHI) in the L22 ribosomal protein gene (rplV) preventing synergistic ribosomal binding of the streptogramin combination. Similar gene duplication has been reported in Q/D-resistant Staphylococcus aureus.

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收藏

页码：2696 / 2698

页数：3

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