Bone mineral density in children with cerebral palsy

Background: The purpose of the present study was to evaluate the severity of and factors related to osteopenia in children with cerebral palsy (CP). Methods: Bone mineral density (BMD), calcium (Ca), phosphate (P), alkaline phosphatase (ALP), creatinine, parathyroid hormone (PTH) and 25-hydroxy vitamin D-3 (25OHD(3)) concentrations were determined in 24 children with CP (15 ambulant, nine non-ambulant), aged between 10 months and 12 years (mean ( +/- SD) 4.1 +/- 2.9 years). These vaules were compared with data obtained from a control group. Results: Adjusted mean BMD values were lower in the patient group than in controls (P < 0.05). However, there was no difference between BMD values of ambulant acid non-ambulant patients, The Ca and P levels of the patient group were significantly higher than those of controls (P < 0.05). Conclusions: The present study showed that BMD was decreased in all children with CP, but to a greater extent in non-ambulant children with CP, and immobilization is the major effective factor on bone mineralization.