Chemokine receptor CXCR3: An unexpected enigma

被引：126

作者：

Liu, LP ^{[1
]}

Callahan, MK ^{[1
]}

Huang, DR ^{[1
]}

Ransohoff, RM ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Neurosci, Lerner Res Inst, Cleveland, OH 44195 USA

来源：

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOLUME 68 | 2005年 / 68卷

关键词：

D O I：

10.1016/S0070-2153(05)68006-4

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CXCR3, the receptor for CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC is preferentially expressed on activated Th1 T cells and has been predicted to play an important role in their trafficking. However, this simplistic view of the function of CXCR3 and its ligands has not been borne out by studies of disease models, including experimental autoimmune encephalomyelitis (EAE), using varied methods of receptor blockade, as well as knockout or transgenic mice. This review focuses on the current understanding of the enigmatic role of CXCR3 and its ligands in CNS inflammatory/autoimmune disorders. The conflicting results among varied models of CNS inflammation suggest complex and multiple roles for CXCR3 and its ligands in the pathogenesis of CNS inflammatory/autoimmune diseases. Thus, further study is needed to determine how CXCL10 neutralizing agents or CXCR3 receptor antagonists might be applied to treating human disease. (c) 2005, Elsevier Inc.

引用

页码：149 / 181

页数：33

共 122 条

[1]

Agace WW, 2000, EUR J IMMUNOL, V30, P819, DOI 10.1002/1521-4141(200003)30:3<819::AID-IMMU819>3.3.CO

[2]

2-P

[3] Early delayed-type hypersensitivity eosinophil infiltrates depend on T helper 2 cytokines and interferon-γ via CXCR3 chemokines [J].

Akahira-Azuma, M ;

Szczepanik, M ;

Tsuji, RF ;

Campos, RA ;

Itakura, A ;

Mobini, N ;

McNiff, J ;

Kawikova, I ;

Lu, B ;

Gerard, C ;

Pober, JS ;

Askenase, PW .

IMMUNOLOGY, 2004, 111 (03) :306-317

[4] Human chemokines: An update [J].

Baggiolini, M ;

Dewald, B ;

Moser, B .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :675-705

[5] INDUCTION OF CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN BIOZZI MICE [J].

BAKER, D ;

ONEILL, JK ;

GSCHMEISSNER, SE ;

WILCOX, CE ;

BUTTER, C ;

TURK, JL .

JOURNAL OF NEUROIMMUNOLOGY, 1990, 28 (03) :261-270

[6] Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients [J].

Baker, MS ;

Chen, XJ ;

Rotramel, AR ;

Nelson, JJ ;

Lu, B ;

Gerard, C ;

Kanwar, Y ;

Kaufman, DB .

SURGERY, 2003, 134 (02) :126-133

[7] CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions [J].

Balashov, KE ;

Rottman, JB ;

Weiner, HL ;

Hancock, WW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6873-6878

[8]

Barone C M, 1993, J Craniofac Surg, V4, P177, DOI 10.1097/00001665-199307000-00013

[9] Functional expression of CXCR3 in cultured mouse and human astrocytes and microglia [J].

Biber, K ;

Dijkstra, I ;

Trebst, C ;

De Groot, CJA ;

Ransohoff, RM ;

Boddeke, HWGM .

NEUROSCIENCE, 2002, 112 (03) :487-497

[10] Ischemia-induced neuronal expression of the microglia attracting chemokine secondary lymphoid-tissue chemokine (SLC) [J].

Biber, K ;

Sauter, A ;

Brouwer, N ;

Copray, SCVM ;

Boddeke, HWGM .

GLIA, 2001, 34 (02) :121-133

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