Abnormalities in the Enamel in Bmp2-Deficient Mice

被引：40

作者：

Feng, Junsheng ^{[3
]}

Yang, Guobin ^{[4
,5
]}

Yuan, Guohua ^{[4
,5
]}

Gluhak-Heinrich, Jelica

Yang, Wuchen

Wang, Lynn

Chen, Zhi ^{[4
,5
]}

McDaniel, Jennifer Schulze

Donly, Kevin J.

Harris, Stephen E.

MacDougall, Mary ^{[2
]}

Chen, Shuo ^{[1
]}

机构：

[1] Univ Texas Hlth Sci Ctr San Antonio, Sch Dent, Dept Dev Dent, San Antonio, TX 78229 USA

[2] Univ Alabama, Sch Dent, Birmingham, AL 35294 USA

[3] Fujian Med Univ, Fuzhou, Peoples R China

[4] Wuhan Univ, Sch Stomatol, Wuhan 430072, Peoples R China

[5] Wuhan Univ, Hosp Stomatol, Wuhan 430072, Peoples R China

来源：

CELLS TISSUES ORGANS | 2011年 / 194卷 / 2-4期

关键词：

Bone morphogenetic protein 2; Conditional knockout; Enamel formation; Amelogenesis imperfecta; BONE MORPHOGENETIC PROTEINS; LINKED AMELOGENESIS IMPERFECTA; AMELOBLASTIN GENE; NF-Y; EXPRESSION; BMP2; MOUSE; DIFFERENTIATION; TRANSCRIPTION; DEFICIENT;

D O I：

10.1159/000324644

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100123 [人体微生态学]; 100210 [外科学];

摘要：

Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (Bmp2) is essential for tooth formation. However, the role of Bmp2 during enamel formation remains unknown in vivo. In this study, the role of Bmp2 in the regulation of postnatal enamel formation was investigated via the conditional ablation of Bmp2 in enamel using the (Osx-Cre) mouse. Bmp2 gene ablation was confirmed by PCR analysis in Osx-Cre, Bmp2(flox/flox) mice. Bmp2-null mice displayed a severe and profound tooth phenotype with asymmetric and open forked incisors. Microradiographs revealed broken incisor tips and dental pulp chamber exposure. The enamel layer of incisors and molars was thin with hypomineralization. Scanning electron microscopy analysis showed that the enamel surface was rough with chipping and the enamel lacked a typical prismatic architecture. These results demonstrate that Bmp2 is essential for enamel formation. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：216 / 221

页数：6

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